Statins can thus also reduce the endogenous synthesis of coenzyme Q 10
Although we have focused on the mitochondria as we believe that this core respiratory deficiency is the most important example of a copper-dependent system as it governs metabolism (Ruiz et al., 2021), it is necessary to point out the key role of other copper-dependent systems that would be compromised in the brain-wide copper deficiency we see in AD
Despite these points, it is crucial to consult with healthcare providers before starting any supplementation, especially during pregnancy
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Miklossy, 2015)
In an ideal world, preclinical and clinical studies would always use the same techniques (e.g., the same anticoagulant for sample collection, process samples from one individual at a time, control for environmental confounds, etc.)